KAT8 (lysine acetyltransferase 8)

2011-08-01  

Identity

HGNC
KAT8
LOCATION
16p11.2
LOCUSID
84148
ALIAS
LIGOWS,MOF,MYST1,ZC2HC8,hMOF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84148
MIM: 609912
HGNC: 17933
Ensembl: ENSG00000103510

Variants:

dbSNP: 84148
ClinVar: 84148
TCGA: ENSG00000103510
COSMIC: KAT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103510ENST00000219797Q9H7Z6
ENSG00000103510ENST00000448516Q9H7Z6
ENSG00000103510ENST00000537402H3BMX5
ENSG00000103510ENST00000543774Q9H7Z6
ENSG00000103510ENST00000652764A0A494C0I2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

References

Pubmed IDYearTitleCitations
381351802024Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation.0
384112742024KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.0
381351802024Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation.0
384112742024KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.0
375665462023MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.0
375665462023MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.0
351918042022Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis.3
351918042022Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis.3
333761382021Dysregulation of intercellular signaling by MOF deletion leads to liver injury.3
334677282021Substrate Scope for Human Histone Lysine Acetyltransferase KAT8.4
335444372021MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma.8
336574002021Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.32
342852252021TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.27
333761382021Dysregulation of intercellular signaling by MOF deletion leads to liver injury.3
334677282021Substrate Scope for Human Histone Lysine Acetyltransferase KAT8.4

Citation

Dessen P

KAT8 (lysine acetyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52336/kat8-(lysine-acetyltransferase-8)