CYFIP2 (cytoplasmic FMR1 interacting protein 2)

2011-08-01  

Identity

HGNC
LOCATION
5q33.3
LOCUSID
ALIAS
DEE65,EIEE65,PIR121
FUSION GENES

Other Information

Locus ID:

NCBI: 26999
MIM: 606323
HGNC: 13760
Ensembl: ENSG00000055163

Variants:

dbSNP: 26999
ClinVar: 26999
TCGA: ENSG00000055163
COSMIC: CYFIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000055163ENST00000435847H7C229
ENSG00000055163ENST00000520960A0A087WZL7
ENSG00000055163ENST00000521420E7EVJ5
ENSG00000055163ENST00000522463E7EW33
ENSG00000055163ENST00000522637E5RKA3
ENSG00000055163ENST00000611075A0A087WVE1
ENSG00000055163ENST00000611925A0A087WTQ3
ENSG00000055163ENST00000616178Q96F07
ENSG00000055163ENST00000617629A0A087WWZ1
ENSG00000055163ENST00000618329Q96F07
ENSG00000055163ENST00000620254Q96F07
ENSG00000055163ENST00000621516A0A087WV63

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381287862024Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.0
381287862024Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.0
377357112023CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers.2
377357112023CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers.2
359558432022Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related to Early Infantile Epileptic Encephalopathy.2
359558432022Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related to Early Infantile Epileptic Encephalopathy.2
331492772021New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics.19
343276612021Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.8
345586362021NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2.3
331492772021New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics.19
343276612021Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.8
345586362021NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2.3
300218652019Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.12
306647142019Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures.26
300218652019Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.12

Citation

Dessen P

CYFIP2 (cytoplasmic FMR1 interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52345/cyfip2