Identity
HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
1110001C14Rik,ATGL,FP17548,PEDF-R,TTS-2.2,TTS2,iPLA2zeta
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57104
MIM: 609059
HGNC: 30802
Ensembl: ENSG00000177666
Variants:
dbSNP: 57104
ClinVar: 57104
TCGA: ENSG00000177666
COSMIC: PNPLA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000177666 | ENST00000336615 | Q96AD5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36604676 | 2023 | BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells. | 3 |
| 37935950 | 2023 | ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression. | 1 |
| 38136930 | 2023 | Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort. | 0 |
| 36604676 | 2023 | BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells. | 3 |
| 37935950 | 2023 | ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression. | 1 |
| 38136930 | 2023 | Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort. | 0 |
| 34387896 | 2022 | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 14 |
| 35676490 | 2022 | ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. | 39 |
| 34387896 | 2022 | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 14 |
| 35676490 | 2022 | ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. | 39 |
| 32777979 | 2021 | Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection. | 7 |
| 33160079 | 2021 | Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals. | 4 |
| 33445064 | 2021 | Dietary fat content and adipose triglyceride lipase and hormone-sensitive lipase gene expressions in adults' subcutaneous and visceral fat tissues. | 2 |
| 33621408 | 2021 | Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway. | 14 |
| 33675111 | 2021 | Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences. | 6 |
Citation
Dessen P
PNPLA2 (patatin like phospholipase domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-08-01
Online version: http://atlasgeneticsoncology.org/gene/52359/pnpla2
