IST1 (IST1 factor associated with ESCRT-III)

2011-09-01  

Identity

HGNC
IST1
LOCATION
16q22.2
LOCUSID
9798
ALIAS
CHMP8,OLC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9798
MIM: 616434
HGNC: 28977
Ensembl: ENSG00000182149

Variants:

dbSNP: 9798
ClinVar: 9798
TCGA: ENSG00000182149
COSMIC: IST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182149ENST00000329908P53990
ENSG00000182149ENST00000378798P53990
ENSG00000182149ENST00000378799P53990
ENSG00000182149ENST00000424485F5GXM3
ENSG00000182149ENST00000439924E9PF00
ENSG00000182149ENST00000456820J3KR23
ENSG00000182149ENST00000534994H3BMU1
ENSG00000182149ENST00000535424P53990
ENSG00000182149ENST00000536027J3QQP8
ENSG00000182149ENST00000537613H3BUI0
ENSG00000182149ENST00000538104H3BQ38
ENSG00000182149ENST00000538850P53990
ENSG00000182149ENST00000539186H3BQF7
ENSG00000182149ENST00000540296H3BPP6
ENSG00000182149ENST00000541571P53990
ENSG00000182149ENST00000541918H3BUI0
ENSG00000182149ENST00000544564P53990
ENSG00000182149ENST00000568581H3BRE2
ENSG00000182149ENST00000606369P53990
ENSG00000182149ENST00000626438E9PF00

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388801672024Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma.0
388801672024Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma.0
358583362022Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1.9
358583362022Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1.9
322514132020Membrane constriction and thinning by sequential ESCRT-III polymerization.38
322514132020Membrane constriction and thinning by sequential ESCRT-III polymerization.38
301106332018Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.44
301106332018Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.44
280384622017Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma.0
285325432017[Overexpression of OLC1 in Lung Squamous Cell Carcinoma Tissues is Associated with Poor Prognosis of Patients].1
280384622017Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma.0
285325432017[Overexpression of OLC1 in Lung Squamous Cell Carcinoma Tissues is Associated with Poor Prognosis of Patients].1
256570072015Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.26
260118582015ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.46
256570072015Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.26

Citation

Dessen P

IST1 (IST1 factor associated with ESCRT-III)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52362