PIEZO1 (piezo type mechanosensitive ion channel component 1)

2011-09-01  

Identity

HGNC
PIEZO1
LOCATION
16q24.3
LOCUSID
9780
ALIAS
DHS,FAM38A,LMPH3,LMPHM6,Mib
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9780
MIM: 611184
HGNC: 28993
Ensembl: ENSG00000103335

Variants:

dbSNP: 9780
ClinVar: 9780
TCGA: ENSG00000103335
COSMIC: PIEZO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103335ENST00000301015Q92508
ENSG00000103335ENST00000327397E7EUT2
ENSG00000103335ENST00000419505H7C2J5
ENSG00000103335ENST00000466823H3BRR7
ENSG00000103335ENST00000474606H0YB49
ENSG00000103335ENST00000518793H3BSF6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379751622024Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.2
380332862024Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.2
380444632024Piezo1-mediated regulation of smooth muscle cell volume in response to enhanced extracellular matrix rigidity.1
381345722024Elucidating the mechanism of IL-1β-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling Pathway.1
381846902024PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome.3
383344772024PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells.1
383386932024The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells.0
383933252024Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells.3
383959922024Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.3
384127632024Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation.0
384678892024Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.0
384949152024PIEZO1 acts as a cancer suppressor by regulating the ROS/Wnt/β-catenin axis.1
385083502024The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress.1
385282022024Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation.1
385302392024Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity.0

Citation

Dessen P

PIEZO1 (piezo type mechanosensitive ion channel component 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52379