CD3G (CD3g molecule)

2011-10-01  

Identity

HGNC
CD3G
LOCATION
11q23.3
LOCUSID
917
ALIAS
CD3-GAMMA,IMD17,T3G
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 917
MIM: 186740
HGNC: 1675
Ensembl: ENSG00000160654

Variants:

dbSNP: 917
ClinVar: 917
TCGA: ENSG00000160654
COSMIC: CD3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160654ENST00000292144J3KNA5
ENSG00000160654ENST00000392883A8MUH3
ENSG00000160654ENST00000528540A0A3B3IUD8
ENSG00000160654ENST00000532917P09693
ENSG00000160654ENST00000532917B0YIY5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Translocation of ZAP-70 to Immunological synapseREACTOMER-HSA-202430
Generation of second messenger moleculesREACTOMER-HSA-202433
Downstream TCR signalingREACTOMER-HSA-202424
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382558222024Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.0
382558222024Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.0
296539652018Patients with CD3G mutations reveal a role for human CD3γ in T(reg) diversity and suppressive function.31
296539652018Patients with CD3G mutations reveal a role for human CD3γ in T(reg) diversity and suppressive function.31
259575932016T cells, mast cells and microvascular density in diffuse large B cell lymphoma.5
259575932016T cells, mast cells and microvascular density in diffuse large B cell lymphoma.5
251133992015Low cord blood Foxp3/CD3γ mRNA ratios: a marker of increased risk for allergy development.5
257606912015Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.7
259209982015Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif.3
261090642015Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.22
251133992015Low cord blood Foxp3/CD3γ mRNA ratios: a marker of increased risk for allergy development.5
257606912015Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.7
259209982015Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif.3
261090642015Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.22
247942512014Infiltration of CD3⁺ and CD68⁺ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.71

Citation

Dessen P

CD3G (CD3g molecule)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52425