ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)

2011-10-01  

Identity

HGNC
ENTPD1
LOCATION
10q24.1
LOCUSID
953
ALIAS
ATPDase,CD39,NTPDase-1,SPG64
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 953
MIM: 601752
HGNC: 3363
Ensembl: ENSG00000138185

Variants:

dbSNP: 953
ClinVar: 953
TCGA: ENSG00000138185
COSMIC: ENTPD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138185ENST00000371205P49961
ENSG00000138185ENST00000371207P49961
ENSG00000138185ENST00000453258P49961
ENSG00000138185ENST00000483213A0A0U1RR44
ENSG00000138185ENST00000543964P49961
ENSG00000138185ENST00000635076A0A0U1RQZ5
ENSG00000138185ENST00000639992A0A1W2PQK8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370556752024Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73).1
374021022024ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis.0
370556752024Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73).1
374021022024ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis.0
356138552023Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.3
367768662023The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy.5
367921242023CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.10
372687262023Human soluble CD39 displays substrate inhibition in a substrate-specific manner.1
375054792023A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance.7
380620682023Cancer CD39 drives metabolic adaption and mal-differentiation of CD4(+) T cells in patients with non-small-cell lung cancer.4
381394392023Elevated CD39+T-Regulatory Cells and Reduced Levels of Adenosine Indicate a Role for Tolerogenic Signals in the Progression from Moderate to Severe COVID-19.1
382757422023Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response.2
356138552023Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.3
367768662023The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy.5
367921242023CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.10

Citation

Dessen P

ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52440