COPZ1 (COPI coat complex subunit zeta 1)

2011-10-01 Affiliation

Identity

HGNC

COPZ1

LOCATION

12q13.13

LOCUSID

22818

ALIAS

CGI-120,COPZ,HSPC181,zeta-COP,zeta1-COP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 22818
MIM: 615472
HGNC: 2243
Ensembl: ENSG00000111481

Variants:

dbSNP: 22818
ClinVar: 22818
TCGA: ENSG00000111481
COSMIC: COPZ1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111481	ENST00000262061	P61923
ENSG00000111481	ENST00000262061	A0A024RB72
ENSG00000111481	ENST00000455864	P61923
ENSG00000111481	ENST00000548753	F8VYK5
ENSG00000111481	ENST00000549043	P61923
ENSG00000111481	ENST00000549116	F8W651
ENSG00000111481	ENST00000550171	F8VUC5
ENSG00000111481	ENST00000550713	F8VXR1
ENSG00000111481	ENST00000551779	F8VYZ4
ENSG00000111481	ENST00000551962	F8W156
ENSG00000111481	ENST00000552218	F8VVA7
ENSG00000111481	ENST00000552362	P61923
ENSG00000111481	ENST00000552848	F8VXB1
ENSG00000111481	ENST00000553231	F8VYE0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434

References

Pubmed ID	Year	Title	Citations
33420375	2021	Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.	74
33420375	2021	Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.	74
28951131	2017	Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells.	10
28951131	2017	Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells.	10
21746916	2011	Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.	26
21746916	2011	Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.	26

Citation

Dessen P

COPZ1 (COPI coat complex subunit zeta 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52450/meetings/cancer-prone-explorer/teaching-explorer/