ATP8A1 (ATPase phospholipid transporting 8A1)

2011-10-01  

Identity

HGNC
ATP8A1
LOCATION
4p13
LOCUSID
10396
ALIAS
ATPASEII,ATPIA,ATPP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10396
MIM: 609542
HGNC: 13531
Ensembl: ENSG00000124406

Variants:

dbSNP: 10396
ClinVar: 10396
TCGA: ENSG00000124406
COSMIC: ATP8A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124406ENST00000264449Q9Y2Q0
ENSG00000124406ENST00000381668Q9Y2Q0
ENSG00000124406ENST00000504024H0YAJ4
ENSG00000124406ENST00000506602H0Y8I6
ENSG00000124406ENST00000510289Q4G1C1
ENSG00000124406ENST00000514372H0YAA1
ENSG00000124406ENST00000515872H0YAF4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384595962024Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.2
384595962024Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.2
339904682021AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.12
339904682021AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells.12
302827212019Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.3
306744562019Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets.5
314169312019Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.85
302827212019Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.3
306744562019Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets.5
314169312019Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.85
304579832018Over-Expression of ATPase II Alleviates Ethanol-Induced Hepatocyte Injury in HL-7702 Cells.1
304579832018Over-Expression of ATPase II Alleviates Ethanol-Induced Hepatocyte Injury in HL-7702 Cells.1
290934432017Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.24
290934432017Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.24
264157322016MiR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer.34

Citation

Dessen P

ATP8A1 (ATPase phospholipid transporting 8A1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52456/case-report-explorer/css/gene-fusions/?id=52456