Identity
HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
KHLHX,KLEIP,KLHLX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27252
MIM: 617679
HGNC: 25056
Ensembl: ENSG00000076321
Variants:
dbSNP: 27252
ClinVar: 27252
TCGA: ENSG00000076321
COSMIC: KLHL20
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000076321 | ENST00000209884 | Q9Y2M5 |
| ENSG00000076321 | ENST00000209884 | A0A024R940 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36214804 | 2022 | De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder. | 1 |
| 36214804 | 2022 | De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder. | 1 |
| 31279627 | 2019 | Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. | 11 |
| 31279627 | 2019 | Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. | 11 |
| 26687681 | 2016 | Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. | 116 |
| 26687681 | 2016 | Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. | 116 |
| 24768539 | 2014 | K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. | 79 |
| 24768539 | 2014 | K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. | 79 |
| 21840486 | 2011 | A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. | 88 |
| 21888897 | 2011 | Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. | 7 |
| 21840486 | 2011 | A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. | 88 |
| 21888897 | 2011 | Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. | 7 |
| 20389280 | 2010 | The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. | 60 |
| 20389280 | 2010 | The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. | 60 |
| 17395875 | 2007 | The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis. | 11 |
Citation
Dessen P
KLHL20 (kelch like family member 20)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/52461/klhl20
