IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))

2011-11-01  

Identity

HGNC
IGHG1
LOCATION
14q32.33
LOCUSID
3500
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3500
MIM: 147100
HGNC: 5525
Ensembl: ENSG00000211896
IMGT/GENE-DB:

Variants:

dbSNP: 3500
ClinVar: 3500
TCGA: ENSG00000211896
COSMIC: IGHG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211896ENST00000390542A0A0A0MS07
ENSG00000211896ENST00000390548A0A0A0MS08
ENSG00000211896ENST00000390549P01857

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Classical antibody-mediated complement activationREACTOMER-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
382682392024Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.0
382682392024Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.0
364046822023High expression of IGHG1 promotes breast cancer malignant development by activating the AKT pathway.3
367360992023CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote melanoma cell proliferation, migration, and invasion.1
364046822023High expression of IGHG1 promotes breast cancer malignant development by activating the AKT pathway.3
367360992023CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote melanoma cell proliferation, migration, and invasion.1
351339762022An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.10
351339762022An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.10
342051752021Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients.2
342051752021Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients.2
313552782019IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway.20
313552782019IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway.20
299453072018Demonstration of IgG Subclass (IgG1 and IgG3) in Immuno-Related Hemocytopenia.1
301988832018Structure of the Fc fragment of the NIST reference antibody RM8671.8
303199942018The Hepatitis B Surface Antigen Binding Protein: An Immunoglobulin G Constant Region-Like Protein That Interacts With HBV Envelop Proteins and Mediates HBV Entry.3

Citation

Dessen P

IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52481