AANAT (aralkylamine N-acetyltransferase)

2011-11-01  

Identity

HGNC
AANAT
LOCATION
17q25.1
LOCUSID
15
ALIAS
DSPS,SNAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 15
MIM: 600950
HGNC: 19
Ensembl: ENSG00000129673

Variants:

dbSNP: 15
ClinVar: 15
TCGA: ENSG00000129673
COSMIC: AANAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129673ENST00000250615Q16613
ENSG00000129673ENST00000392492Q16613
ENSG00000129673ENST00000392492F1T0I5
ENSG00000129673ENST00000585649K7ESH7
ENSG00000129673ENST00000587798K7ERF6

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Melatonin biosynthesis, tryptophan => serotonin => melatoninKEGGhsa_M00037
Melatonin biosynthesis, tryptophan => serotonin => melatoninKEGGM00037
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Serotonin and melatonin biosynthesisREACTOMER-HSA-209931

References

Pubmed IDYearTitleCitations
387539692024Variation in the AA-NAT gene G203A is associated with Awassi and Hamdani sheep fertility.0
387539692024Variation in the AA-NAT gene G203A is associated with Awassi and Hamdani sheep fertility.0
341844922021[Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].0
347631652021Downregulation of AANAT by c-Fos in tubular epithelial cells with membranous nephropathy.3
341844922021[Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].0
347631652021Downregulation of AANAT by c-Fos in tubular epithelial cells with membranous nephropathy.3
318151522019Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population.1
318151522019Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population.1
283683072017TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level.5
286991742017Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.17
283683072017TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level.5
286991742017Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.17
273399002016Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.9
273399002016Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.9
214376222011Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands.25

Citation

Dessen P

AANAT (aralkylamine N-acetyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52492