IFIT1 (interferon induced protein with tetratricopeptide repeats 1)

2011-11-01  

Identity

HGNC
IFIT1
LOCATION
10q23.31
LOCUSID
3434
ALIAS
C56,G10P1,IFI-56,IFI-56K,IFI56,IFIT-1,IFNAI1,ISG56,P56,RNM561
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3434
MIM: 147690
HGNC: 5407
Ensembl: ENSG00000185745

Variants:

dbSNP: 3434
ClinVar: 3434
TCGA: ENSG00000185745
COSMIC: IFIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185745ENST00000371804P09914
ENSG00000185745ENST00000546318P09914

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374962882023Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.3
378172242023Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1.0
374962882023Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.3
378172242023Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1.0
347632332021Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.7
347632332021Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.7
314449472020Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.9
319770292020Expression and Prognostic Value of IFIT1 and IFITM3 in Head and Neck Squamous Cell Carcinoma.11
323639512020ISG56 is involved in CXCL10 expression induced by TLR3 signaling in BEAS-2B bronchial epithelial cells.4
329628612020Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies.1
314449472020Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.9
319770292020Expression and Prognostic Value of IFIT1 and IFITM3 in Head and Neck Squamous Cell Carcinoma.11
323639512020ISG56 is involved in CXCL10 expression induced by TLR3 signaling in BEAS-2B bronchial epithelial cells.4
329628612020Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies.1
306269372019IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling.43

Citation

Dessen P

IFIT1 (interferon induced protein with tetratricopeptide repeats 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52498