Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23643
MIM: 605243
HGNC: 17156
Ensembl: ENSG00000154589
Variants:
dbSNP: 23643
ClinVar: 23643
TCGA: ENSG00000154589
COSMIC: LY96
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000154589 | ENST00000284818 | Q9Y6Y9 |
| ENSG00000154589 | ENST00000518893 | Q9Y6Y9 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 28696418 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 28696418 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37885279 | 2024 | Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2. | 2 |
| 38135694 | 2024 | Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target. | 1 |
| 37885279 | 2024 | Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2. | 2 |
| 38135694 | 2024 | Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target. | 1 |
| 35502635 | 2022 | Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy. | 3 |
| 35502635 | 2022 | Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy. | 3 |
| 33495414 | 2021 | Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. | 7 |
| 33841413 | 2021 | Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. | 6 |
| 33495414 | 2021 | Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. | 7 |
| 33841413 | 2021 | Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. | 6 |
| 32424165 | 2020 | HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway. | 8 |
| 32424165 | 2020 | HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway. | 8 |
| 30959420 | 2019 | Structural variants of Salmonella Typhimurium lipopolysaccharide induce less dimerization of TLR4/MD-2 and reduced pro-inflammatory cytokine production in human monocytes. | 7 |
| 31032920 | 2019 | The effects and mechanisms of myeloid differentiation protein 2 on intestinal mucosal permeability in mice with chronic colitis. | 4 |
| 31180798 | 2019 | Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection. | 3 |
Citation
Dessen P
LY96 (lymphocyte antigen 96)
Atlas Genet Cytogenet Oncol Haematol. 2011-12-01
Online version: http://atlasgeneticsoncology.org/gene/52505/ly96
