Identity
HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
I-1,IR1,IRAS,hIRAS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11188
MIM: 615507
HGNC: 18006
Ensembl: ENSG00000010322
Variants:
dbSNP: 11188
ClinVar: 11188
TCGA: ENSG00000010322
COSMIC: NISCH
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000010322 | ENST00000345716 | Q9Y2I1 |
| ENSG00000010322 | ENST00000420808 | Q9Y2I1 |
| ENSG00000010322 | ENST00000479054 | Q9Y2I1 |
| ENSG00000010322 | ENST00000488380 | C9J715 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36716956 | 2023 | Contribution of Nischarin/IRAS in CNS development, injury and diseases. | 1 |
| 37382661 | 2023 | Nischarin expression may have differing roles in male and female melanoma patients. | 1 |
| 37443018 | 2023 | Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. | 0 |
| 36716956 | 2023 | Contribution of Nischarin/IRAS in CNS development, injury and diseases. | 1 |
| 37382661 | 2023 | Nischarin expression may have differing roles in male and female melanoma patients. | 1 |
| 37443018 | 2023 | Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. | 0 |
| 34727954 | 2021 | Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis. | 10 |
| 34727954 | 2021 | Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis. | 10 |
| 29415725 | 2018 | Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells. | 14 |
| 29415725 | 2018 | Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells. | 14 |
| 28131840 | 2017 | Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer. | 7 |
| 28461172 | 2017 | Upregulation of IRAS/nischarin (I(1)-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers. | 5 |
| 28131840 | 2017 | Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer. | 7 |
| 28461172 | 2017 | Upregulation of IRAS/nischarin (I(1)-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers. | 5 |
| 26363797 | 2016 | IRAS Modulates Opioid Tolerance and Dependence by Regulating μ Opioid Receptor Trafficking. | 5 |
Citation
Dessen P
NISCH (nischarin)
Atlas Genet Cytogenet Oncol Haematol. 2011-12-01
Online version: http://atlasgeneticsoncology.org/gene/52509/nisch
