HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)

2011-07-01 Affiliation

Identity

HGNC

HLA-DPA1

LOCATION

6p21.32

LOCUSID

3113

ALIAS

DP(W3),DP(W4),DPA1,HLA-DP1A,HLA-DPA,HLA-DPB1,HLADP,HLASB,PLT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3113
MIM: 142880
HGNC: 4938
Ensembl: ENSG00000231389

Variants:

dbSNP: 3113
ClinVar: 3113
TCGA: ENSG00000231389
COSMIC: HLA-DPA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000231389	ENST00000417724	F6V115
ENSG00000231389	ENST00000419277	P20036
ENSG00000231389	ENST00000419277	X5CKE2
ENSG00000231389	ENST00000437811	H0Y6F8
ENSG00000231389	ENST00000453337	J3KQ99

Expression (GTEx)

100

200

300

400

500

600

700

800

900

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Antigen processing and presentation	KEGG	ko04612
Hematopoietic cell lineage	KEGG	ko04640
Type I diabetes mellitus	KEGG	ko04940
Asthma	KEGG	ko05310
Autoimmune thyroid disease	KEGG	ko05320
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Antigen processing and presentation	KEGG	hsa04612
Hematopoietic cell lineage	KEGG	hsa04640
Type I diabetes mellitus	KEGG	hsa04940
Asthma	KEGG	hsa05310
Autoimmune thyroid disease	KEGG	hsa05320
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Viral myocarditis	KEGG	hsa05416
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Phosphorylation of CD3 and TCR zeta chains	REACTOME	R-HSA-202427
Translocation of ZAP-70 to Immunological synapse	REACTOME	R-HSA-202430
Generation of second messenger molecules	REACTOME	R-HSA-202433
Downstream TCR signaling	REACTOME	R-HSA-202424
Costimulation by the CD28 family	REACTOME	R-HSA-388841
PD-1 signaling	REACTOME	R-HSA-389948
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation	associated		PD	26387494
PA446862	Hepatitis B, Chronic	Disease	ClinicalAnnotation	associated		PD	26387494

References

Pubmed ID	Year	Title	Citations
37980631	2024	The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility.	0
38454348	2024	Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration.	0
38932664	2024	Characterisation of five new variants of HLA-DPA1.	0
37980631	2024	The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility.	0
38454348	2024	Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration.	0
38932664	2024	Characterisation of five new variants of HLA-DPA1.	0
36342183	2023	Identification of the novel HLA-DPA101:03:43 allele resulting from an intralocus recombination involving the DPA104:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS).	0
36412220	2023	Identification of HLA-DPA101:03:01:57 and HLA-DPA102:01:01:29 from a case-control study of atopic dermatitis.	0
36974749	2023	Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension.	2
37899135	2023	HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma.	1
36342183	2023	Identification of the novel HLA-DPA101:03:43 allele resulting from an intralocus recombination involving the DPA104:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS).	0
36412220	2023	Identification of HLA-DPA101:03:01:57 and HLA-DPA102:01:01:29 from a case-control study of atopic dermatitis.	0
36974749	2023	Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension.	2
37899135	2023	HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma.	1
34536062	2022	Characterization of the novel HLA-DPA1 allele, HLA-DPA1*01:86.	0

Citation

Dessen P

HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52523