HOXB2 (homeobox B2)

2012-01-01  

Identity

HGNC
HOXB2
LOCATION
17q21.32
LOCUSID
3212
ALIAS
HOX2,HOX2H,Hox-2.8,K8

Other Information

Locus ID:

NCBI: 3212
MIM: 142967
HGNC: 5113
Ensembl: ENSG00000173917

Variants:

dbSNP: 3212
ClinVar: 3212
TCGA: ENSG00000173917
COSMIC: HOXB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173917ENST00000330070P14652

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
383221212024The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling.0
386170012024Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1.0
383221212024The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling.0
386170012024Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1.0
353204862023High expression of homeobox B2 predicts poor survival of colon adenocarcinoma by enhancing tumor proliferation and invasion.0
353204862023High expression of homeobox B2 predicts poor survival of colon adenocarcinoma by enhancing tumor proliferation and invasion.0
333000852021miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2.12
334593772021HOXB-AS1 accelerates the tumorigenesis of glioblastoma via modulation of HOBX2 and HOBX3 at transcriptional and posttranscriptional levels.9
340622582021Estrogen suppresses HOXB2 expression via ERα in breast cancer cells.2
333000852021miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2.12
334593772021HOXB-AS1 accelerates the tumorigenesis of glioblastoma via modulation of HOBX2 and HOBX3 at transcriptional and posttranscriptional levels.9
340622582021Estrogen suppresses HOXB2 expression via ERα in breast cancer cells.2
320140082020Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma.13
321965762020MiR-202-5p suppressed cell proliferation, migration and invasion in ovarian cancer via regulating HOXB2.18
324457512020HOXB2 and FOXC1 synergistically drive the progression of Wilms tumor.6

Citation

Dessen P

HOXB2 (homeobox B2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52538/gene-explorer/css/lib/css/card-gene.css