Identity
HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
COXPD29,MT-TRX,MTRX,TRX2,TXN
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25828
MIM: 609063
HGNC: 17772
Ensembl: ENSG00000100348
Variants:
dbSNP: 25828
ClinVar: 25828
TCGA: ENSG00000100348
COSMIC: TXN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100348 | ENST00000216185 | Q99757 |
| ENSG00000100348 | ENST00000403313 | Q99757 |
| ENSG00000100348 | ENST00000411915 | F8WDN2 |
| ENSG00000100348 | ENST00000416967 | M0QXH0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38003443 | 2023 | scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma. | 0 |
| 38003443 | 2023 | scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma. | 0 |
| 34688818 | 2022 | Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study. | 3 |
| 34688818 | 2022 | Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study. | 3 |
| 32920833 | 2021 | Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression. | 4 |
| 33763469 | 2021 | Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris. | 6 |
| 32920833 | 2021 | Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression. | 4 |
| 33763469 | 2021 | Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris. | 6 |
| 31915282 | 2020 | Thioredoxin 2 Negatively Regulates Innate Immunity to RNA Viruses by Disrupting the Assembly of the Virus-Induced Signaling Adaptor Complex. | 2 |
| 31915282 | 2020 | Thioredoxin 2 Negatively Regulates Innate Immunity to RNA Viruses by Disrupting the Assembly of the Virus-Induced Signaling Adaptor Complex. | 2 |
| 28045936 | 2017 | Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury. | 8 |
| 28130258 | 2017 | Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension. | 10 |
| 28356525 | 2017 | MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. | 18 |
| 28914755 | 2017 | Thioredoxin 2 Offers Protection against Mitochondrial Oxidative Stress in H9c2 Cells and against Myocardial Hypertrophy Induced by Hyperglycemia. | 19 |
| 28045936 | 2017 | Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury. | 8 |
Citation
Dessen P
TXN2 (thioredoxin 2)
Atlas Genet Cytogenet Oncol Haematol. 2012-01-01
Online version: http://atlasgeneticsoncology.org/gene/52545/txn2
