CFL2 (cofilin 2)

2012-02-01  

Identity

HGNC
LOCATION
14q13.1
LOCUSID
ALIAS
NEM7
FUSION GENES

Other Information

Locus ID:

NCBI: 1073
MIM: 601443
HGNC: 1875
Ensembl: ENSG00000165410

Variants:

dbSNP: 1073
ClinVar: 1073
TCGA: ENSG00000165410
COSMIC: CFL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165410ENST00000298159Q9Y281
ENSG00000165410ENST00000298159Q549N0
ENSG00000165410ENST00000341223Q9Y281
ENSG00000165410ENST00000341223Q549N0
ENSG00000165410ENST00000422678F8WDN3
ENSG00000165410ENST00000554470G3V2U0
ENSG00000165410ENST00000555765Q9Y281
ENSG00000165410ENST00000556161Q9Y281
ENSG00000165410ENST00000672163Q549N0
ENSG00000165410ENST00000672517Q549N0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Regulation of actin cytoskeletonKEGGko04810
Axon guidanceKEGGhsa04360
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
PertussisKEGGko05133
PertussisKEGGhsa05133

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380036452023Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization.0
380036452023Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization.0
343240292022Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis.5
354401002022Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode.8
343240292022Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis.5
354401002022Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode.8
321602862020Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype.4
328632282020Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation.7
321602862020Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype.4
328632282020Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation.7
306629432019Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α(4)β(7) integrin antibody.13
316238302019Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis.18
306629432019Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α(4)β(7) integrin antibody.13
316238302019Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis.18
293428412018miR-3189-3p Mimics Enhance the Effects of S100A4 siRNA on the Inhibition of Proliferation and Migration of Gastric Cancer Cells by Targeting CFL2.14

Citation

Dessen P

CFL2 (cofilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52583/cfl2