Identity
HGNC
LOCATION
3q29
LOCUSID
ALIAS
BERHS,MGM1,MTDPS14,NPG,NTG,largeG
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4976
MIM: 605290
HGNC: 8140
Ensembl: ENSG00000198836
Variants:
dbSNP: 4976
ClinVar: 4976
TCGA: ENSG00000198836
COSMIC: OPA1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Programmed Cell Death | REACTOME | R-HSA-5357801 |
| Apoptosis | REACTOME | R-HSA-109581 |
| Regulation of Apoptosis | REACTOME | R-HSA-169911 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38101398 | 2024 | Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function. | 1 |
| 38151998 | 2024 | p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer. | 0 |
| 38280232 | 2024 | OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. | 0 |
| 38404440 | 2024 | Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases. | 0 |
| 39039850 | 2024 | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | 0 |
| 38101398 | 2024 | Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function. | 1 |
| 38151998 | 2024 | p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer. | 0 |
| 38280232 | 2024 | OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. | 0 |
| 38404440 | 2024 | Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases. | 0 |
| 39039850 | 2024 | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | 0 |
| 36418744 | 2023 | Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease. | 0 |
| 36596388 | 2023 | SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics. | 11 |
| 36675156 | 2023 | p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification. | 2 |
| 36927155 | 2023 | OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion. | 4 |
| 36980838 | 2023 | Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts. | 1 |
Citation
Dessen P
OPA1 (OPA1 mitochondrial dynamin like GTPase)
Atlas Genet Cytogenet Oncol Haematol. 2012-02-01
Online version: http://atlasgeneticsoncology.org/gene/52594/opa1
