PFN2 (profilin 2)

2012-02-01  

Identity

HGNC
PFN2
LOCATION
3q25.1
LOCUSID
5217
ALIAS
D3S1319E,PFL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5217
MIM: 176590
HGNC: 8882
Ensembl: ENSG00000070087

Variants:

dbSNP: 5217
ClinVar: 5217
TCGA: ENSG00000070087
COSMIC: PFN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070087ENST00000239940P35080
ENSG00000070087ENST00000423691G5E9Q6
ENSG00000070087ENST00000452853P35080
ENSG00000070087ENST00000460404C9J5V8
ENSG00000070087ENST00000461868C9JQ45
ENSG00000070087ENST00000461930C9J5V8
ENSG00000070087ENST00000468323F2Z3G0
ENSG00000070087ENST00000475518C9J712
ENSG00000070087ENST00000481275C9J712
ENSG00000070087ENST00000481767C9J0J7
ENSG00000070087ENST00000489155C9J712
ENSG00000070087ENST00000490975C9J2N0
ENSG00000070087ENST00000494827C9J0J7
ENSG00000070087ENST00000497148C9J712
ENSG00000070087ENST00000498169F2Z3G0
ENSG00000070087ENST00000498307C9J712
ENSG00000070087ENST00000649949C9J712

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
ShigellosisKEGGhsa05131
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385390842024Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.0
385390842024Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.0
376767182023ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.1
376767182023ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.1
353654452022[Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration].1
354139902022OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer.6
356133092022MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2.5
353654452022[Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration].1
354139902022OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer.6
356133092022MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2.5
330472722021Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells.9
342382152021ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.13
330472722021Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells.9
342382152021ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.13
319080052020Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics.11

Citation

Dessen P

PFN2 (profilin 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52601