SOCS5 (suppressor of cytokine signaling 5)

2012-03-01  

Identity

HGNC
LOCATION
2p21
LOCUSID
ALIAS
CIS6,CISH6,Cish5,SOCS-5

Other Information

Locus ID:

NCBI: 9655
MIM: 607094
HGNC: 16852
Ensembl: ENSG00000171150

Variants:

dbSNP: 9655
ClinVar: 9655
TCGA: ENSG00000171150
COSMIC: SOCS5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171150ENST00000306503O75159
ENSG00000171150ENST00000394861O75159
ENSG00000171150ENST00000650009A0A3B3ISP4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376462612023Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.1
376729632023Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study.0
378285342023Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.0
376462612023Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.1
376729632023Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study.0
378285342023Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.0
351213742022Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus.3
357304722022SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.4
351213742022Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus.3
357304722022SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.4
346666132021LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.16
346666132021LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.16
312331162020MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5.30
321553482020lncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT Pathway.18
322118042020miR-802 participates in the inflammatory process of inflammatory bowel disease by suppressing SOCS5.3

Citation

Dessen P

SOCS5 (suppressor of cytokine signaling 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52610/socs5