Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 152
MIM: 104250
HGNC: 283
Ensembl: ENSG00000184160
Variants:
dbSNP: 152
ClinVar: 152
TCGA: ENSG00000184160
COSMIC: ADRA2C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000184160 | ENST00000330055 | P18825 |
| ENSG00000184160 | ENST00000330055 | Q4W594 |
| ENSG00000184160 | ENST00000509482 | D6RGL0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165945764 | bucindolol | Chemical | ClinicalAnnotation | associated | PD | 23071495 | |
| PA444370 | Heart Failure | Disease | ClinicalAnnotation | associated | PD | 23071495 | |
| PA444797 | Liver Cirrhosis | Disease | ClinicalAnnotation | associated | PD | 20833658 | |
| PA448665 | brimonidine | Chemical | Pathway | associated | |||
| PA449051 | clonidine | Chemical | ClinicalAnnotation, Pathway | associated | PD | 20833658 | |
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA451946 | yohimbine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35258481 | 2022 | Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy. | 2 |
| 35258481 | 2022 | Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy. | 2 |
| 34237656 | 2021 | α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. | 5 |
| 34237656 | 2021 | α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. | 5 |
| 31218733 | 2019 | Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients. | 20 |
| 31218733 | 2019 | Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients. | 20 |
| 29552726 | 2018 | α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands. | 14 |
| 30273604 | 2018 | Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. | 4 |
| 29552726 | 2018 | α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands. | 14 |
| 30273604 | 2018 | Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. | 4 |
| 26739946 | 2016 | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate. | 2 |
| 27007576 | 2016 | Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence. | 2 |
| 26739946 | 2016 | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate. | 2 |
| 27007576 | 2016 | Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence. | 2 |
| 25406899 | 2015 | Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy. | 3 |
Citation
Dessen P
ADRA2C (adrenoceptor alpha 2C)
Atlas Genet Cytogenet Oncol Haematol. 2012-03-01
Online version: http://atlasgeneticsoncology.org/gene/52616/adra2c
