CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

2012-03-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 79094
MIM: 614587
HGNC: 28680
Ensembl: ENSG00000128965

Variants:

dbSNP: 79094
ClinVar: 79094
TCGA: ENSG00000128965
COSMIC: CHAC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128965ENST00000444189Q9BUX1
ENSG00000128965ENST00000487220H0YK90
ENSG00000128965ENST00000617768Q9BUX1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387691932024Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer.0
387691932024Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer.0
366750912023CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.12
369160932023CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2 cells by promoting oxidative stress.5
382473332023CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma.0
366750912023CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.12
369160932023CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2 cells by promoting oxidative stress.5
382473332023CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma.0
359301442022High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues.5
359301442022High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues.5
337287492021Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.39
337287492021Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.39
329493692020Transcriptomic analysis of the effect of (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl) prop-2-en-1-one (DPP23) on reactive oxygen species generation in MIA PaCa-2 pancreatic cancer cells.0
329493692020Transcriptomic analysis of the effect of (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl) prop-2-en-1-one (DPP23) on reactive oxygen species generation in MIA PaCa-2 pancreatic cancer cells.0
311115702019CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi.10

Citation

Dessen P

CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52619/favicon/js/lib/css/template-nav.css