SIGLEC8 (sialic acid binding Ig like lectin 8)

2012-04-01  

Identity

HGNC
SIGLEC8
LOCATION
19q13.41
LOCUSID
27181
ALIAS
SAF2,SIGLEC-8,SIGLEC8L

Other Information

Locus ID:

NCBI: 27181
MIM: 605639
HGNC: 10877
Ensembl: ENSG00000105366

Variants:

dbSNP: 27181
ClinVar: 27181
TCGA: ENSG00000105366
COSMIC: SIGLEC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105366ENST00000321424Q9NYZ4
ENSG00000105366ENST00000340550Q9NYZ4
ENSG00000105366ENST00000430817C9JT30

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336704442021First Evidence for a Role of Siglec-8 in Breast Cancer.3
337551132021Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis.5
336704442021First Evidence for a Role of Siglec-8 in Breast Cancer.3
337551132021Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis.5
320777882020Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma.4
320777882020Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma.4
305438182019Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.24
305438182019Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.24
287348452018Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells.31
288887812018Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β(2)-integrin-dependent function in human eosinophils.29
287348452018Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells.31
288887812018Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β(2)-integrin-dependent function in human eosinophils.29
266940372016Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.15
268832542016Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection.5
271543552016Olig2 is expressed late in human eosinophil development and controls Siglec-8 expression.10

Citation

Dessen P

SIGLEC8 (sialic acid binding Ig like lectin 8)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52676