PSPC1 (paraspeckle component 1)

2012-05-01  

Identity

HGNC
PSPC1
LOCATION
13q12.11
LOCUSID
55269
ALIAS
PSP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55269
MIM: 612408
HGNC: 20320
Ensembl: ENSG00000121390

Variants:

dbSNP: 55269
ClinVar: 55269
TCGA: ENSG00000121390
COSMIC: PSPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121390ENST00000338910Q8WXF1
ENSG00000121390ENST00000427943X6RDA4
ENSG00000121390ENST00000471658Q8WXF1
ENSG00000121390ENST00000471658A0A024RDP4
ENSG00000121390ENST00000492741Q8WXF1
ENSG00000121390ENST00000492741A0A024RDP4
ENSG00000121390ENST00000619300Q8WXF1
ENSG00000121390ENST00000635562A0A0U1RQF9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362658782023Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation.6
372099202023Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer.0
362658782023Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation.6
372099202023Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer.0
346996432022Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.4
356810312022PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2.5
346996432022Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.4
356810312022PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2.5
325709492020PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.8
328441952020Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.5
325709492020PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.8
328441952020Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.5
318440572019PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.19
318440572019PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression.19
294836552018RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells.82

Citation

Dessen P

PSPC1 (paraspeckle component 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52703/gene-explorer/meetings/