FRMD6 (FERM domain containing 6)

2012-05-01  

Identity

HGNC
FRMD6
LOCATION
14q22.1
LOCUSID
122786
ALIAS
C14orf31,EX1,Willin,c14_5320
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 122786
MIM: 614555
HGNC: 19839
Ensembl: ENSG00000139926

Variants:

dbSNP: 122786
ClinVar: 122786
TCGA: ENSG00000139926
COSMIC: FRMD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139926ENST00000344768Q96NE9
ENSG00000139926ENST00000356218Q96NE9
ENSG00000139926ENST00000395718Q96NE9
ENSG00000139926ENST00000553556Q96NE9
ENSG00000139926ENST00000554778G3V517
ENSG00000139926ENST00000555197H0YJC1
ENSG00000139926ENST00000555703G3V2L4
ENSG00000139926ENST00000557405H0YJ19

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383852112024High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients.0
383852112024High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients.0
355015942022CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis.5
355015942022CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis.5
332494272021FRMD6 has tumor suppressor functions in prostate cancer.10
332494272021FRMD6 has tumor suppressor functions in prostate cancer.10
319179932020The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma.16
319179932020The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma.16
311289102019MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.9
311289102019MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.9
280798912017CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.22
280798912017CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.22
276611202016FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases.12
276611202016FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases.12
216667192012Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.58

Citation

Dessen P

FRMD6 (FERM domain containing 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52707/haematological-explorer/tumors-explorer/