ECD (ecdysoneless cell cycle regulator)

2012-05-01  

Identity

HGNC
ECD
LOCATION
10q22.2
LOCUSID
11319
ALIAS
GCR2,HSGT1,SGT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11319
MIM: 616464
HGNC: 17029
Ensembl: ENSG00000122882

Variants:

dbSNP: 11319
ClinVar: 11319
TCGA: ENSG00000122882
COSMIC: ECD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122882ENST00000372979O95905
ENSG00000122882ENST00000413026C9JGV1
ENSG00000122882ENST00000430082O95905
ENSG00000122882ENST00000453402C9J316
ENSG00000122882ENST00000454759O95905
ENSG00000122882ENST00000484976F2Z2R1
ENSG00000122882ENST00000494307S4R458

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
356750412022Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.1
356750412022Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.1
297066182018ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.22
297066182018ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.22
256165802015The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.9
267112702015A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.15
256165802015The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.9
267112702015A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.15
238803452013TXNIP interacts with hEcd to increase p53 stability and activity.14
238803452013TXNIP interacts with hEcd to increase p53 stability and activity.14
222709302012Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.18
229771922012Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.25
222709302012Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.18
229771922012Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.25
199191812010Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation.8

Citation

Dessen P

ECD (ecdysoneless cell cycle regulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52712