TCN1 (transcobalamin 1)

2012-06-01 Affiliation

Identity

HGNC

TCN1

LOCATION

11q12.1

LOCUSID

6947

ALIAS

HC,TC-1,TC1,TCI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6947
MIM: 189905
HGNC: 11652
Ensembl: ENSG00000134827

Variants:

dbSNP: 6947
ClinVar: 6947
TCGA: ENSG00000134827
COSMIC: TCN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134827	ENST00000257264	P20061

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolism	REACTOME	R-HSA-196741
Neutrophil degranulation	REACTOME	R-HSA-6798695

References

Pubmed ID	Year	Title	Citations
35686504	2023	TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells by Regulating the ITGB4 Pathway.	1
37209861	2023	Reference intervals and stability of haptocorrin and holotranscobalamin in Danish children and elderly.	1
37586352	2023	TCN1 Expression Is Increased in Asthma.	0
35686504	2023	TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells by Regulating the ITGB4 Pathway.	1
37209861	2023	Reference intervals and stability of haptocorrin and holotranscobalamin in Danish children and elderly.	1
37586352	2023	TCN1 Expression Is Increased in Asthma.	0
34549663	2022	Clinicopathological Analysis and Prognostic Assessment of TCN1 in Patients with Gastric Cancer.	2
34549663	2022	Clinicopathological Analysis and Prognostic Assessment of TCN1 in Patients with Gastric Cancer.	2
32753569	2020	Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors.	6
32753569	2020	Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors.	6
29764838	2018	A common TCN1 loss-of-function variant is associated with lower vitamin B(12) concentration in African Americans.	6
29764838	2018	A common TCN1 loss-of-function variant is associated with lower vitamin B(12) concentration in African Americans.	6
26959381	2016	Association study between genome-wide significant variants of vitamin B12 metabolism and gastric cancer in a han Chinese population.	12
27577703	2016	Vitamin B12 and placental expression of transcobalamin in pregnant adolescents.	6
26959381	2016	Association study between genome-wide significant variants of vitamin B12 metabolism and gastric cancer in a han Chinese population.	12

Citation

Dessen P

TCN1 (transcobalamin 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52729