HTR1B (5-hydroxytryptamine receptor 1B)

2012-06-01  

Identity

HGNC
HTR1B
LOCATION
6q14.1
LOCUSID
3351
ALIAS
5-HT-1B,5-HT-1D-beta,5-HT1B,5-HT1DB,HTR1D2,HTR1DB,S12

Other Information

Locus ID:

NCBI: 3351
MIM: 182131
HGNC: 5287
Ensembl: ENSG00000135312

Variants:

dbSNP: 3351
ClinVar: 3351
TCGA: ENSG00000135312
COSMIC: HTR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135312ENST00000369947P28222
ENSG00000135312ENST00000369947X5D7I5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD
PA164778866liothyronineChemicalClinicalAnnotationassociatedPD21449676
PA172GNAI1GenePathwayassociated19741567
PA173GNAI3GenePathwayassociated19741567
PA24347GNAI2GenePathwayassociated19741567
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD27324805
PA447278DepressionDiseaseClinicalAnnotationassociatedPD21449676
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD27324805, 28025020
PA449015citalopramChemicalClinicalAnnotationassociatedPD27324805
PA449048clomipramineChemicalClinicalAnnotationassociatedPD21449676
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD28025020
PA450243lithiumChemicalClinicalAnnotationassociatedPD21449676
PA450603nefazodoneChemicalClinicalAnnotationassociatedPD21449676
PA450801paroxetineChemicalClinicalAnnotationassociated21449676
PA451866venlafaxineChemicalClinicalAnnotationassociatedPD21449676

References

Pubmed IDYearTitleCitations
380503282024The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study.0
380503282024The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study.0
377621362023Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.1
377621362023Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.1
354383032022Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder.2
358533822022HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment.2
354383032022Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder.2
358533822022HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment.2
320922112020Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.3
326695692020The discovery of a new antibody for BRIL-fused GPCR structure determination.12
326899512020Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation.2
330032792020First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development.4
330365802020Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders.1
332449612020[The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones].1
320922112020Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.3

Citation

Dessen P

HTR1B (5-hydroxytryptamine receptor 1B)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52736