HTRA4 (HtrA serine peptidase 4)

0000-00-00  

Identity

HGNC
HTRA4
LOCATION
8p11.22
LOCUSID
203100
ALIAS
-

Other Information

Locus ID:

NCBI: 203100
MIM: 610700
HGNC: 26909
Ensembl: ENSG00000169495

Variants:

dbSNP: 203100
ClinVar: 203100
TCGA: ENSG00000169495
COSMIC: HTRA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169495ENST00000302495P83105

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383250512024HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast.0
388806012024Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast.0
383250512024HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast.0
388806012024Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast.0
372965802023Cellular Functions of High-Temperature Requirement Factor A4 in Placenta.1
375796942023Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling.0
372965802023Cellular Functions of High-Temperature Requirement Factor A4 in Placenta.1
375796942023Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling.0
342573672021HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4.9
342573672021HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4.9
320565552020Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.10
320565552020Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.10
306389492019Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.6
308044772019HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia.9
310367152019Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway.6

Citation

Dessen P

HTRA4 (HtrA serine peptidase 4)

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/gene/52757/css/img/logo-atlas-4.svg