Identity
HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
CMT1F,CMT2E,CMTDIG,NF-L,NF68,NFL,PPP1R110
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4747
MIM: 162280
HGNC: 7739
Ensembl: ENSG00000277586
Variants:
dbSNP: 4747
ClinVar: 4747
TCGA: ENSG00000277586
COSMIC: NEFL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000277586 | ENST00000610854 | P07196 |
| ENSG00000277586 | ENST00000619417 | A0A087X0W2 |
| ENSG00000277586 | ENST00000639464 | A0A0S2Z436 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37314537 | 2024 | Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism. | 1 |
| 37530894 | 2024 | Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study. | 2 |
| 37545369 | 2024 | Inflammation affects dynamic functional network connectivity pattern changes via plasma NFL in cognitive impairment patients. | 1 |
| 37797300 | 2024 | Plasma neurofilament light chain predicts Alzheimer's disease in patients with subjective cognitive decline and mild cognitive impairment: A cross-sectional and longitudinal study. | 5 |
| 37843431 | 2024 | Plasma neurofilament light chain in association to late-life depression in the general population. | 1 |
| 38339819 | 2024 | Relationship between increased serum neurofilament light chain and glial fibrillary acidic protein levels with non-motor symptoms in patients with Parkinson's disease. | 0 |
| 38347655 | 2024 | The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study. | 0 |
| 38627748 | 2024 | Cluster analysis dissecting cognitive deficits in older adults with major depressive disorder and the association with neurofilament light chain. | 0 |
| 37314537 | 2024 | Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism. | 1 |
| 37530894 | 2024 | Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study. | 2 |
| 37545369 | 2024 | Inflammation affects dynamic functional network connectivity pattern changes via plasma NFL in cognitive impairment patients. | 1 |
| 37797300 | 2024 | Plasma neurofilament light chain predicts Alzheimer's disease in patients with subjective cognitive decline and mild cognitive impairment: A cross-sectional and longitudinal study. | 5 |
| 37843431 | 2024 | Plasma neurofilament light chain in association to late-life depression in the general population. | 1 |
| 38339819 | 2024 | Relationship between increased serum neurofilament light chain and glial fibrillary acidic protein levels with non-motor symptoms in patients with Parkinson's disease. | 0 |
| 38347655 | 2024 | The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study. | 0 |
Citation
Dessen P
NEFL (neurofilament light chain)
Atlas Genet Cytogenet Oncol Haematol. 2012-07-01
Online version: http://atlasgeneticsoncology.org/gene/52777/nefl
