CERS1 (ceramide synthase 1)

2012-07-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
EPM8,GDF-1,GDF1,LAG1,LASS1,UOG1

Other Information

Locus ID:

NCBI: 10715
MIM: 606919
HGNC: 14253
Ensembl: ENSG00000223802

Variants:

dbSNP: 10715
ClinVar: 10715
TCGA: ENSG00000223802
COSMIC: CERS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223802ENST00000429504P27544
ENSG00000223802ENST00000542296Q5XG75
ENSG00000223802ENST00000596048M0R0T2
ENSG00000223802ENST00000623882P27544
ENSG00000223802ENST00000623927A0A024R7N8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Ceramide biosynthesisKEGGM00094
Sphingosine biosynthesisKEGGM00099
Ceramide biosynthesisKEGGhsa_M00094
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385069022024Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.1
385069022024Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.1
332677082020The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma.1
332677082020The Potential Role of CERS1 in Autophagy Through PI3K/AKT Signaling Pathway in Hypophysoma.1
269135182016Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians.7
269135182016Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians.7
221802942012Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.30
231609952012CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches.24
221802942012Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.30
231609952012CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches.24
198008812010Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.22
205692352010HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.43
205692352010HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.43
198008812010Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.22
205692352010HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.43

Citation

Dessen P

CERS1 (ceramide synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-07-01

Online version: http://atlasgeneticsoncology.org/gene/52780/cers1