CACTIN (cactin, spliceosome C complex subunit)

2012-08-01  

Identity

HGNC
CACTIN
LOCATION
19p13.3
LOCUSID
58509
ALIAS
C19orf29,NY-REN-24,fSAPc
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58509
MIM: 618536
HGNC: 29938
Ensembl: ENSG00000105298

Variants:

dbSNP: 58509
ClinVar: 58509
TCGA: ENSG00000105298
COSMIC: CACTIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105298ENST00000221899Q8WUQ7
ENSG00000105298ENST00000248420Q8WUQ7
ENSG00000105298ENST00000429344Q8WUQ7
ENSG00000105298ENST00000585942Q8WUQ7
ENSG00000105298ENST00000588749K7EQE3
ENSG00000105298ENST00000589321K7EMQ0
ENSG00000105298ENST00000591726K7EIU6
ENSG00000105298ENST00000592721K7ENY9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
280628512017Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.12
280628512017Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.12
263635542016TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.25
263635542016TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.25
260331102015Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone.3
260331102015Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone.3
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

CACTIN (cactin, spliceosome C complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52793/cactin