Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2444
MIM: 606573
HGNC: 3955
Ensembl: ENSG00000111816
Variants:
dbSNP: 2444
ClinVar: 2444
TCGA: ENSG00000111816
COSMIC: FRK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111816 | ENST00000606080 | P42685 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36070195 | 2023 | Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish. | 1 |
| 36070195 | 2023 | Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish. | 1 |
| 35723276 | 2022 | FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. | 3 |
| 35723276 | 2022 | FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. | 3 |
| 31251822 | 2020 | FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming. | 10 |
| 31883420 | 2020 | TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma. | 17 |
| 31894485 | 2020 | Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK). | 2 |
| 31907296 | 2020 | Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas. | 10 |
| 31996378 | 2020 | Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. | 9 |
| 33277858 | 2020 | GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK. | 8 |
| 31251822 | 2020 | FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming. | 10 |
| 31883420 | 2020 | TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma. | 17 |
| 31894485 | 2020 | Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK). | 2 |
| 31907296 | 2020 | Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas. | 10 |
| 31996378 | 2020 | Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. | 9 |
Citation
Dessen P
FRK (fyn related Src family tyrosine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/528/frk
