VANGL2 (VANGL planar cell polarity protein 2)

2010-03-01  

Identity

HGNC
VANGL2
LOCATION
1q23.2
LOCUSID
57216
ALIAS
LPP1,LTAP,STB1,STBM,STBM1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57216
MIM: 600533
HGNC: 15511
Ensembl: ENSG00000162738

Variants:

dbSNP: 57216
ClinVar: 57216
TCGA: ENSG00000162738
COSMIC: VANGL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162738ENST00000368061Q9ULK5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
378159312024Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish.0
386691832024Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.0
378159312024Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish.0
386691832024Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.0
338243322021Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling.24
338243322021Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling.24
304720972019VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.2
304720972019VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.2
294991542018Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.40
301253612018Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury.13
294991542018Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.40
301253612018Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury.13
290971832017VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.9
290971832017VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.9
267547712016Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.59

Citation

Dessen P

VANGL2 (VANGL planar cell polarity protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52810/vangl2