ALX4 (ALX homeobox 4)

2010-03-01 Affiliation

Identity

HGNC

ALX4

LOCATION

11p11.2

LOCUSID

60529

ALIAS

CRS5,FND2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 60529
MIM: 605420
HGNC: 450
Ensembl: ENSG00000052850

Variants:

dbSNP: 60529
ClinVar: 60529
TCGA: ENSG00000052850
COSMIC: ALX4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000052850	ENST00000652299	Q9H161

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
37724761	2023	Dominant frontonasal dysplasia with ectodermal defects results from increased activity of ALX4.	0
37724761	2023	Dominant frontonasal dysplasia with ectodermal defects results from increased activity of ALX4.	0
33369125	2021	Vertical transmission of a large calvarial ossification defect due to heterozygous variants of ALX4 and TWIST1.	1
34586326	2021	De novo ALX4 variant detected in child with non-syndromic craniosynostosis.	2
33369125	2021	Vertical transmission of a large calvarial ossification defect due to heterozygous variants of ALX4 and TWIST1.	1
34586326	2021	De novo ALX4 variant detected in child with non-syndromic craniosynostosis.	2
31791584	2020	miR-1470 regulates cell proliferation and apoptosis by targeting ALX4 in hepatocellular carcinoma.	4
32385972	2020	Variants in ALX4 and their association with genitourinary defects.	1
32856218	2020	Overexpression of circ_0001445 decelerates hepatocellular carcinoma progression by regulating miR-942-5p/ALX4 axis.	9
31791584	2020	miR-1470 regulates cell proliferation and apoptosis by targeting ALX4 in hepatocellular carcinoma.	4
32385972	2020	Variants in ALX4 and their association with genitourinary defects.	1
32856218	2020	Overexpression of circ_0001445 decelerates hepatocellular carcinoma progression by regulating miR-942-5p/ALX4 axis.	9
28081728	2017	Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.	8
29183346	2017	ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway.	15
28081728	2017	Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells.	8

Citation

Dessen P

ALX4 (ALX homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52812/css/lib/img/gene-explorer/