AGO1 (argonaute RISC component 1)

2010-03-01  

Identity

HGNC
AGO1
LOCATION
1p34.3
LOCUSID
26523
ALIAS
EIF2C,EIF2C1,GERP95,Q99,hAgo1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26523
MIM: 606228
HGNC: 3262
Ensembl: ENSG00000092847

Variants:

dbSNP: 26523
ClinVar: 26523
TCGA: ENSG00000092847
COSMIC: AGO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092847ENST00000373204Q9UL18
ENSG00000092847ENST00000373206Q5TA58
ENSG00000092847ENST00000635259A0A0U1RQZ8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

References

Pubmed IDYearTitleCitations
369902272023LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.0
369902272023LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.0
349308162022De novo coding variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability.6
350601142022De novo variants in AGO1 recapitulate a heterogeneous neurodevelopmental disorder phenotype.1
361424982022Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.2
349308162022De novo coding variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability.6
350601142022De novo variants in AGO1 recapitulate a heterogeneous neurodevelopmental disorder phenotype.1
361424982022Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.2
327529542021Molecular crowding and conserved interface interactions of human argonaute protein-miRNA-target mRNA complex.1
333277132021Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN.0
336004932021RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.12
338324812021POU2F2 promotes the proliferation and motility of lung cancer cells by activating AGO1.6
342883732021LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-β pathway via miR-148a-3p/AGO1 axis.9
327529542021Molecular crowding and conserved interface interactions of human argonaute protein-miRNA-target mRNA complex.1
333277132021Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN.0

Citation

Dessen P

AGO1 (argonaute RISC component 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52819