THEMIS (thymocyte selection associated)

2012-08-01 Affiliation

Identity

HGNC

THEMIS

LOCATION

6q22.33

LOCUSID

387357

ALIAS

C6orf190,C6orf207,GASP,SPOT,TSEPA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 387357
MIM: 613607
HGNC: 21569
Ensembl: ENSG00000172673

Variants:

dbSNP: 387357
ClinVar: 387357
TCGA: ENSG00000172673
COSMIC: THEMIS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172673	ENST00000368248	Q8N1K5
ENSG00000172673	ENST00000368250	Q8N1K5
ENSG00000172673	ENST00000434358	X1WI26
ENSG00000172673	ENST00000537166	Q8N1K5
ENSG00000172673	ENST00000626040	A0A0D9SFD2
ENSG00000172673	ENST00000630369	Q8N1K5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32004441	2020	THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.	74
32004441	2020	THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.	74
28250424	2017	THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.	47
28250424	2017	THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.	47
27438997	2016	Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis.	7
27438997	2016	Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis.	7
25535246	2015	A THEMIS:SHP1 complex promotes T-cell survival.	54
25535246	2015	A THEMIS:SHP1 complex promotes T-cell survival.	54
23820479	2014	THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge.	18
23820479	2014	THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge.	18
23460737	2013	GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.	41
23460737	2013	GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.	41
22610119	2012	Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.	800
22732588	2012	Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.	24
22610119	2012	Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.	800

Citation

Dessen P

THEMIS (thymocyte selection associated)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52829