ALPK2 (alpha kinase 2)

2012-08-01  

Identity

HGNC
ALPK2
LOCATION
18q21.31
LOCUSID
115701
ALIAS
HAK

Other Information

Locus ID:

NCBI: 115701
HGNC: 20565
Ensembl: ENSG00000198796

Variants:

dbSNP: 115701
ClinVar: 115701
TCGA: ENSG00000198796
COSMIC: ALPK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198796ENST00000361673Q86TB3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
337054082021A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women.2
342109562021ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.4
347056172021Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis.2
337054082021A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women.2
342109562021ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.4
347056172021Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis.2
323305082020Knockdown of ALPK2 blocks development and progression of renal cell carcinoma.6
323305082020Knockdown of ALPK2 blocks development and progression of renal cell carcinoma.6
286688862017An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.2
286688862017An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.2
226416662012ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.17
226416662012ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.17
196908902009Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.9
196908902009Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.9

Citation

Dessen P

ALPK2 (alpha kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52830