GCSAM (germinal center associated signaling and motility)

2012-09-01  

Identity

HGNC
GCSAM
LOCATION
3q13.2
LOCUSID
257144
ALIAS
GCAT2,GCET2,HGAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 257144
MIM: 607792
HGNC: 20253
Ensembl: ENSG00000174500

Variants:

dbSNP: 257144
ClinVar: 257144
TCGA: ENSG00000174500
COSMIC: GCSAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174500ENST00000308910Q8N6F7
ENSG00000174500ENST00000460387Q8N6F7
ENSG00000174500ENST00000470085F2Z3F7
ENSG00000174500ENST00000484193Q8N6F7
ENSG00000174500ENST00000487901C9IY73
ENSG00000174500ENST00000488580C9JY41
ENSG00000174500ENST00000495418F2Z3F7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375191102023Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell Lymphoma.0
375191102023Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell Lymphoma.0
330249962021Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice.2
345433912021HGAL inhibits lymphoma dissemination by interacting with multiple cytoskeletal proteins.1
330249962021Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice.2
345433912021HGAL inhibits lymphoma dissemination by interacting with multiple cytoskeletal proteins.1
315707562020Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.8
315707562020Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.8
313629272019Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.6
313629272019Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.6
252034282015Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms.7
253810612015HGAL localization to cell membrane regulates B-cell receptor signaling.14
252034282015Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms.7
253810612015HGAL localization to cell membrane regulates B-cell receptor signaling.14
229146132013Usefulness of HGAL and LMO2 immunohistochemistry in the identification of follicular lymphomas of the non-gastric gastrointestinal tract.0

Citation

Dessen P

GCSAM (germinal center associated signaling and motility)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52852/css/lib/teaching-explorer/