IGKC (immunoglobulin kappa constant)

2012-09-01  

Identity

HGNC
IGKC
LOCATION
2p11.2
LOCUSID
3514
ALIAS
HCAK1,IGKCD,Km
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3514
MIM: 147200
HGNC: 5716
Ensembl: ENSG00000211592
IMGT/GENE-DB:

Variants:

dbSNP: 3514
ClinVar: 3514
TCGA: ENSG00000211592
COSMIC: IGKC

RNA/Proteins

Expression (GTEx)

0
5000
10000
15000
20000
25000
30000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
378949002023Prognostic Impact of CD38- and IgκC-Positive Tumor-Infiltrating Plasma Cells in Triple-Negative Breast Cancer.1
378949002023Prognostic Impact of CD38- and IgκC-Positive Tumor-Infiltrating Plasma Cells in Triple-Negative Breast Cancer.1
329519072021Metachronous and clonally related classic Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma.0
329519072021Metachronous and clonally related classic Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma.0
322785842020A rare case of selective Igκ chain deficiency: Biologic and clinical implications.1
327957352020Prognostic value of kappa free light chains determination in first-ever multiple sclerosis relapse.10
322785842020A rare case of selective Igκ chain deficiency: Biologic and clinical implications.1
327957352020Prognostic value of kappa free light chains determination in first-ever multiple sclerosis relapse.10
296832292018Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer.5
296832292018Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer.5
240549452014IGKC and FcγR genotypes and humoral immunity to HER2 in breast cancer.11
243041362014Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.2
240549452014IGKC and FcγR genotypes and humoral immunity to HER2 in breast cancer.11
243041362014Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.2
233036722013High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.43

Citation

Dessen P

IGKC (immunoglobulin kappa constant)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52874