FAAP20 (FA core complex associated protein 20)

2012-09-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
C1orf86,FP7162
FUSION GENES

Other Information

Locus ID:

NCBI: 199990
MIM: 615183
HGNC: 26428
Ensembl: ENSG00000162585

Variants:

dbSNP: 199990
ClinVar: 199990
TCGA: ENSG00000162585
COSMIC: FAAP20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162585ENST00000378543Q6NZ36
ENSG00000162585ENST00000378546Q6NZ36
ENSG00000162585ENST00000400918Q6NZ36
ENSG00000162585ENST00000400919F6S8H2
ENSG00000162585ENST00000414253Q6NZ36
ENSG00000162585ENST00000420515H7C361
ENSG00000162585ENST00000428120H7C2E6
ENSG00000162585ENST00000440825H7C3A6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376203972023Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks.0
376203972023Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks.0
327639752020Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.1
327639752020Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.1
272327582016FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation.12
272327582016FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation.12
263188592015Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain.1
263188592015Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain.1
254143542014Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.6
254143542014Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.6
223439152012FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.64
223965922012Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.57
227053712012A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.47
223439152012FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.64
223965922012Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.57

Citation

Dessen P

FAAP20 (FA core complex associated protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52875/deep-insight-explorer/js/lib/haematological-explorer/