B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)

2012-09-01  

Identity

HGNC
B3GNT5
LOCATION
3q27.1
LOCUSID
84002
ALIAS
B3GN-T5,beta3Gn-T5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84002
MIM: 615333
HGNC: 15684
Ensembl: ENSG00000176597

Variants:

dbSNP: 84002
ClinVar: 84002
TCGA: ENSG00000176597
COSMIC: B3GNT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176597ENST00000326505Q9BYG0
ENSG00000176597ENST00000460419Q9BYG0
ENSG00000176597ENST00000464191C9IYY0
ENSG00000176597ENST00000464923C9J5K2
ENSG00000176597ENST00000465010Q9BYG0
ENSG00000176597ENST00000481531C9J368

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4CerKEGGhsa_M00070
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGhsa_M00071
Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4CerKEGGM00070
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4CerKEGGM00071
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
326773402020B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas.14
326773402020B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas.14
224118382012High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients.25
224118382012High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients.25
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.57
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.57
184836242008Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.47
184836242008Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.47

Citation

Dessen P

B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52877/tumors-explorer/img/gene-fusions/?id=52877