TUBA1C (tubulin alpha 1c)

2012-09-01  

Identity

HGNC
TUBA1C
LOCATION
12q13.12
LOCUSID
84790
ALIAS
TUBA6,bcm948
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84790
HGNC: 20768
Ensembl: ENSG00000167553

Variants:

dbSNP: 84790
ClinVar: 84790
TCGA: ENSG00000167553
COSMIC: TUBA1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167553ENST00000301072Q9BQE3
ENSG00000167553ENST00000541364F5H5D3
ENSG00000167553ENST00000549183F8VS66
ENSG00000167553ENST00000549818F8VRK1
ENSG00000167553ENST00000552125H0YHV2
ENSG00000167553ENST00000552448F8VRK1
ENSG00000167553ENST00000639419A0A1W2PQM2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Tight junctionKEGGko04530
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
ApoptosisKEGGhsa04210
Tight junctionKEGGhsa04530
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369415952023TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.2
369415952023TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.2
348451652022Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.5
355137902022The oncogenic role of tubulin alpha-1c chain in human tumours.10
348451652022Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.5
355137902022The oncogenic role of tubulin alpha-1c chain in human tumours.10
336541962021Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.9
345172102021TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.14
336541962021Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.9
345172102021TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.14
325991392020Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.9
325991392020Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.9
219657432011Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.4
219657432011Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.4

Citation

Dessen P

TUBA1C (tubulin alpha 1c)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52889/haematological-explorer/css/template-card.css