LINC00598 long intergenic non-protein coding RNA 598
2007-11-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Description
Start at 39,822,377 bp from pter; the gene spans 119,929 bases on minus strand.
Transcription
Three splicing forms, namely: TTL-T, TTL-B1 and -B2. TTL-T is 2090 bp long and composed of exons 1-8. The longest open-reading frame contains exons 4, 5, and part of exon 6; it encods a 133 amino acids peptid. TTL-B1 transcript is 3450 bp long and is composed of exons 4, 5, and part of exon 9. TTL-B2, 3588 bp long is composed of exons 4, 5, and part of exon 8a.
Proteins
Note
This gene/protein remains poorly known: there has been no study on it since the princeps paper by Qiao et al (2003).
Expression
Ubiquitous expression (lung, liver, spleen, thymus, and bone marrow); major expression in brain and testis.
Homology
TTL has no homology to known genes.
Implicated in
Entity name
Note
Only one case to date.
Hybrid gene
Both reciprocal transcripts, TTL/ETV6 and ETV6/TTL, were detected. ETV6/TTL fusion transcript
The other transcript, TTL/ETV6, comprises 5 TTL exons 1 to 5 or to 8a, fused to ETV6 from exon 2. The predicted 530 amino acids fusion protein consists mostly of ETV6 with both HLH and ETS domains, and could have modified transcriptional activities. On the other hand, a loss of function of ETV6 and/or of TTL.could play the critical role in leukemogenesis.
The other transcript, TTL/ETV6, comprises 5 TTL exons 1 to 5 or to 8a, fused to ETV6 from exon 2. The predicted 530 amino acids fusion protein consists mostly of ETV6 with both HLH and ETS domains, and could have modified transcriptional activities. On the other hand, a loss of function of ETV6 and/or of TTL.could play the critical role in leukemogenesis.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12764377 | 2003 | Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis. | Qiao Y et al |
Other Information
Locus ID:
NCBI: 646982
HGNC: 42770
Ensembl: ENSG00000215483
Variants:
dbSNP: 646982
ClinVar: 646982
TCGA: ENSG00000215483
COSMIC: LINC00598
RNA/Proteins
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28339037 | 2017 | The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. | 11 |
| 28339037 | 2017 | The long non-coding RNA lncFOXO1 suppresses growth of human breast cancer cells through association with BAP1. | 11 |
| 27572135 | 2016 | Long noncoding RNA linc00598 regulates CCND2 transcription and modulates the G1 checkpoint. | 10 |
| 27572135 | 2016 | Long noncoding RNA linc00598 regulates CCND2 transcription and modulates the G1 checkpoint. | 10 |
Citation
Jean-Loup Huret
LINC00598 long intergenic non-protein coding RNA 598
Atlas Genet Cytogenet Oncol Haematol. 2007-11-01
Online version: http://atlasgeneticsoncology.org/gene/529/linc00598
