IRGM (immunity related GTPase M)

2012-10-01  

Identity

HGNC
IRGM
LOCATION
5q33.1
LOCUSID
345611
ALIAS
IFI1,IRGM1,LRG-47,LRG47

Other Information

Locus ID:

NCBI: 345611
MIM: 608212
HGNC: 29597
Ensembl: ENSG00000237693

Variants:

dbSNP: 345611
ClinVar: 345611
TCGA: ENSG00000237693
COSMIC: IRGM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000237693ENST00000520549H0YBM2
ENSG00000237693ENST00000522154A1A4Y4

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145

References

Pubmed IDYearTitleCitations
379930852024IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.3
385148982024Impact of IRGM gene promoter polymorphisms on susceptibility to chronic HBV infection.0
379930852024IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.3
385148982024Impact of IRGM gene promoter polymorphisms on susceptibility to chronic HBV infection.0
365807252023IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury.1
366294402023Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.8
369991772023Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.0
375589242023Race-specific association of an IRGM risk allele with cytokine expression in human subjects.0
377050612023TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.1
365807252023IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury.1
366294402023Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.8
369991772023Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.0
375589242023Race-specific association of an IRGM risk allele with cytokine expression in human subjects.0
377050612023TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.1
356613322022Association of IRGM gene promoter polymorphisms with hepatitis B virus infection.0

Citation

Dessen P

IRGM (immunity related GTPase M)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52901