PGD (phosphogluconate dehydrogenase)

2012-10-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
6PGD
FUSION GENES

Other Information

Locus ID:

NCBI: 5226
MIM: 172200
HGNC: 8891
Ensembl: ENSG00000142657

Variants:

dbSNP: 5226
ClinVar: 5226
TCGA: ENSG00000142657
COSMIC: PGD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142657ENST00000270776P52209
ENSG00000142657ENST00000460189K7EPF6
ENSG00000142657ENST00000465632K7EMN2
ENSG00000142657ENST00000477958K7EJT3
ENSG00000142657ENST00000483936K7ELN9
ENSG00000142657ENST00000491493K7EM49

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Glutathione metabolismKEGGko00480
Pentose phosphate pathwayKEGGhsa00030
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100
Pentose phosphate pathway (Pentose phosphate cycle)KEGGhsa_M00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGhsa_M00006
Pentose phosphate pathway (Pentose phosphate cycle)KEGGM00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGM00006
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Pentose phosphate pathway (hexose monophosphate shunt)REACTOMER-HSA-71336

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370711292023Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.0
370711292023Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.0
327193312020HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors.14
3282978020206PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.6
327193312020HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors.14
3282978020206PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.6
301822122019Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.14
301822122019Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.14
295349642018Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.17
295349642018Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.17
2647931820156-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.118
2647931820156-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.118
2412503620141p36.22 region containing PGD gene is frequently gained in human cervical cancer.2
250428032014Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.58
2412503620141p36.22 region containing PGD gene is frequently gained in human cervical cancer.2

Citation

Dessen P

PGD (phosphogluconate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52911/favicon/meetings/