PGD (phosphogluconate dehydrogenase)

2012-10-01  

Identity

HGNC
PGD
LOCATION
1p36.22
LOCUSID
5226
ALIAS
6PGD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5226
MIM: 172200
HGNC: 8891
Ensembl: ENSG00000142657

Variants:

dbSNP: 5226
ClinVar: 5226
TCGA: ENSG00000142657
COSMIC: PGD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142657ENST00000270776P52209
ENSG00000142657ENST00000460189K7EPF6
ENSG00000142657ENST00000465632K7EMN2
ENSG00000142657ENST00000477958K7EJT3
ENSG00000142657ENST00000483936K7ELN9
ENSG00000142657ENST00000491493K7EM49

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Glutathione metabolismKEGGko00480
Pentose phosphate pathwayKEGGhsa00030
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100
Pentose phosphate pathway (Pentose phosphate cycle)KEGGhsa_M00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGhsa_M00006
Pentose phosphate pathway (Pentose phosphate cycle)KEGGM00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGM00006
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Pentose phosphate pathway (hexose monophosphate shunt)REACTOMER-HSA-71336

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370711292023Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.0
370711292023Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.0
327193312020HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors.14
3282978020206PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.6
327193312020HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors.14
3282978020206PGD Upregulation is Associated with Chemo- and Immuno-Resistance of Renal Cell Carcinoma via AMPK Signaling-Dependent NADPH-Mediated Metabolic Reprograming.6
301822122019Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.14
301822122019Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.14
295349642018Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.17
295349642018Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.17
2647931820156-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.118
2647931820156-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.118
2412503620141p36.22 region containing PGD gene is frequently gained in human cervical cancer.2
250428032014Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.58
2412503620141p36.22 region containing PGD gene is frequently gained in human cervical cancer.2

Citation

Dessen P

PGD (phosphogluconate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52911/img/teaching-explorer/