RSPO3 (R-spondin 3)

2012-10-01 Affiliation

Identity

HGNC

RSPO3

LOCATION

6q22.33

LOCUSID

84870

ALIAS

CRISTIN1,PWTSR,THSD2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84870
MIM: 610574
HGNC: 20866
Ensembl: ENSG00000146374

Variants:

dbSNP: 84870
ClinVar: 84870
TCGA: ENSG00000146374
COSMIC: RSPO3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000146374	ENST00000356698	Q9BXY4
ENSG00000146374	ENST00000368317	Q9BXY4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Regulation of FZD by ubiquitination	REACTOME	R-HSA-4641263

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37173190	2023	Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis.	1
37932819	2023	Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.	0
37173190	2023	Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis.	1
37932819	2023	Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.	0
35995979	2022	RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes.	2
36129915	2022	Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.	0
35995979	2022	RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes.	2
36129915	2022	Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.	0
33320737	2021	R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.	6
34389713	2021	RSPO3 is important for trabecular bone and fracture risk in mice and humans.	16
33320737	2021	R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.	6
34389713	2021	RSPO3 is important for trabecular bone and fracture risk in mice and humans.	16
31851527	2020	R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.	7
31990902	2020	Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies.	1
32160239	2020	Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.	16

Citation

Dessen P

RSPO3 (R-spondin 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52917